Results
| PMID | 9130910 |
| Gene Name | AMH |
| Condition | Endometriosis |
| Association |
Women with PCOS had higher serum and follicular fluid MIS levels, a higher percentage of immature oocytes, and lower fertilization rates than women with endometriosis or pelvic adhesions. |
| Population size | 66 |
| Population details | 66 (20 with tubal factor infertility, 17 with polycystic ovary syndrome (PCOS), 29 with endometriosis) |
| Sex | Female |
| Other associated phenotypes |
PCOS, Endometriosis, |
|
Fertil Steril. 1997 May;67(5):962-5. Fallat, M E| Siow, Y| Marra, M| Cook, C| Carrillo, A Department of Surgery, University of Louisville, USA. OBJECTIVE: To determine Mullerian inhibiting substance (MIS) levels in follicular fluid (FF) and sera of IVF patients. DESIGN: Prospective study. SETTING: Fertility center. PATIENT(S): Sixty-six patients: 20 with tubal factor infertility, 17 with polycystic ovary syndrome (PCOS), and 29 with endometriosis. INTERVENTION(S): All patients underwent ovarian stimulation with hMG and/or FSH, as well as oocyte retrieval for IVF. MAIN OUTCOME MEASURE(S): Follicular fluid and serum MIS levels and oocyte fertilization rates. RESULT(S): Levels of MIS in FF and sera of PCOS patients were significantly higher than those in tubal factor patients: 7.01 +/- 1.52 versus 1.65 +/- 0.23 ng/mL (mean +/- SE) and 2.97 +/- 0.52 versus 0.92 +/- 0.19 ng/mL, respectively. In endometriosis patients, follicular fluid and serum MIS levels were not significantly different from those in tubal factor patients. In PCOS patients, the percentage of immature oocytes retrieved (17.9% +/- 5.0%) was significantly higher compared with tubal factor (1.5% +/- 1.0%) and endometriosis (9.2% +/- 2.3%) patients. The percentage of oocytes fertilize was significantly lower in PCOS patients (30.2% +/- 5.3%) compared with tubal factor (62.2% +/- 5.5%) and endometriosis (37.5% +/- 5.7%) patients. CONCLUSION(S): Women with PCOS had higher serum and follicular fluid MIS levels, a higher percentage of immature oocytes, and lower fertilization rates than women with endometriosis or pelvic adhesions. Mesh Terms: Adult| Anti-Mullerian Hormone| Endometriosis/blood/complications/*metabolism| Fallopian Tube Diseases/blood/complications/*metabolism| Female| Fertilization in Vitro| Follicle Stimulating Hormone/therapeutic use| Follicular Fluid/*metabolism| *Gly |
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